Through genuine partnership with our customers, in the Life Science industry, HORIBA will develop and deliver, innovative analytical and automation solutions, combining state-of-the-art, optical, electrochemical, and X-ray technologies, with core competencies in sampling, engineering and data science. HORIBA will contribute to breakthroughs in drug development and manufacturing, leading to the adoption of new technologies, and contributing to a healthier, more affordable and more equitable health care for all.

Life Science

A highly advanced analyzer solves the mysteries of the nano-world. A single device analyzes the three parameters that characterize nanoparticles: particle size, zeta potential, and molecular weight.&nbsp;Nanotechnology research and development is a continuously evolving effort to control substances at the atomic and molecular level in order to achieve new and better materials and products. The miniaturization of components – that is, control at the nano-level – is necessary to achieve faster, higher-performance devices and functions and to reduce energy consumption. Nanotechnology has come to play a key role in wide-ranging fields that affect our daily lives, including food, cosmetics, and the life sciences.&nbsp;Clear and simple multi-parameter analysis of nanoparticles!&nbsp;Three analyzers in a single compact body deliver high-sensitivity, high-accuracy analysis of each measurement parameter.

NanoPartica SZ-100V2(ls)

Model

Particle size measurement: Dynamic Light ScatteringMolecular weight measurement: Debye plot method (static scattered light intensity)

Measurement principles

Particle size: 0.3 nm to 10 μm Molecular weight: 1000 to 2 x 107 Da (Debye plot) 540 to 2 x 107 Da (MHS Equation)*1

Measurement range

Maximum sample concentration

Measurement accuracy of ±2% for NIST traceable polystyrene latex 100 nm spheres (not including variation in the standard particles themselves)

Particle size measurement accuracy

90° and 173° (automatic or manual selection)

Measurement angles

Cells

Approx. 2 min. under ordinary conditions (from the start of measurement to the display of results for particle size measurement)

Measurement time

Minimum volume of 12 μL*3 to 1000 μL (differs depending on cell material)

Required sample volume

Usable liquids

NanoPartica SZ-100V2

HORIBA's new LA-350 Laser Diffraction Particle Size Distribution Analyzer is the ideal combination of performance, price, and packaging. The LA-350 excels in applications as diverse as slurries, minerals, and paper chemistry. Based on the advanced optical design of previous LA-series analyzers, the LA-350 strikes a harmonious balance between high-functionality, easy operation, low maintenance, and cost-effectiveness.&nbsp;Bench space is used efficiently due to the LA-350’s compact size (297 mm x 420 mm). The clever design and precision, high quality manufacturing ensure convenient, reliable operation and accurate results, now with a wider size range (0.1-1,000 µm).&nbsp;In addition, access to world class HORIBA support and training comes with purchase of all HORIBA products. HORIBA offers scheduled service agreements, regular instructional videos, and scheduled classes. HORIBA customers not only have the best analyzers in the business, they are the best analysts in the business.

partica mini LA-350

Laser Scattering Particle Size Distribution Analyzer

Laser diffraction and Mie light scattering theory

Size Measurement range

Typical measurement takes about 10 seconds from Measure to display the result

Analysis Time

Analysis Materials

Particle size and size distribution, size related theoretical calculated values

Measurement Output

Wet method: Liquid dispersed particles with flow sampling system

Measurement Method

10 mg-5 g (depending on the sample size, distribution and materials)

Required Sample Amount

Wet Flow System Liquid Volume

Available in solvent resistant flow sampling version or fraction cell system (optional)

Organic Solvent Compatibility

HORIBA selected NIST traceable standard materials

Measurement Performance Guarantee

Interface

Data Processing/Results Displa

15° to 35° C 85% RH or less (non-condensing)

Operating Conditions

Power

W 297mm x D 420mm x H 376mm (excluding PC)

Dimensions

Mass

Light source: Laser diode 5mW, λ=650nm Analyzer Classification: Class 1A laser product Detectors: 64 ring detectors x 1, Silicon photo detectors x 6

Optics

Ultrasonic: Ultrasonic probe inside of the flow system, 7 steps power adjustment Circulation pumping system: Centrifugal pump, 15 steps of speed control Drain: Solenoid valve Flow cell material: Borosilicate glass

Wet Sampling System

Fraction cell, Auto fill pump, Solvent resistant circulation system

Optional Accessories

partica mini LA-350(ls)

The Veloci A-TEEM BioPharma Analyzer contains innovative, column-free molecular fingerprinting technology designed for the biopharma and pharma industries. By integrating the selectivity of chromatography with the benefits of optical spectroscopy, Veloci offers a fast, simple, and cost-effective method for comprehensive component analysis in various industrial QC/QA life science applications.&nbsp;&nbsp;Unlike traditional methods such as chromatography and mass spectrometry, Veloci’s A-TEEM™ Molecular Fingerprinting technology provides component analysis without time consuming and slow separations. This allows simplified workflows and drastically reduces ownership costs. This versatile tool requires no sample preparation and is suitable for a wide range of applications, including monoclonal antibody discrimination, cell media monitoring, vaccine characterization, protein stability analysis, and AAV quantification.&nbsp;&nbsp;The Veloci A-TEEM BioPharma Analyzer enables label-free intrinsic fluorescence analysis, offering high accuracy and efficiency in research, production and QC/QA environments.

Veloci

Parts per billion (sample and wavelength dependent) 

Detection Limit

Excitation/Absorbance Wavelength Range 

Fluorescence Emission Wavelength Range

Wavelength Accuracy

As fast as 60 seconds (sample and wavelength dependent).

EEM/A-TEEM Acquisition Rate

Remote fiber optic probe, Autosampler with flow cell

Minimum Sample Volume

Sample Handling, Internal 

Approximately 180 mL for standard pumping system, 5/10/15 mL for Fraction Cell accessory, Manual filling : 35 mL, Automatic filling : 40 mL for MiniFlow accessory. Approximately 1 L of LiterFlow option.

Sample Handling, External 

Light Source

Validation 

25.3 in x 18 in x 14.5 in; 642.6 mm x 457.2 mm x 368.3 mm

Dimensions (W x D x H)

In-line ultrasonic probe: 30 W, 20 kHz, adjustable levels Circulation pump: Fully automated ﬁll and circulation pumps, 15 adjustable speeds, 4 selectable fill levels, 15 selectable circulation speeds (max: 10 L/min)

Dispersion System

Weight

The PoliSpectra® RPR is a high-speed, non-destructive Raman plate reader built for high-throughput screening (HTS) workflows. Equipped with patent-pending rapid Raman reading technology and a plate heater, it delivers real-time reaction monitoring in as little as one minute per 96-well plate. Designed for seamless integration, the system features full automation—motorized door, OPC-UA or REST API control, and compatibility with robotic liquid handling and other lab automation systems.

Polispectra Raman Plate Reader

Laser Wavelength

Laser power for 532 nm

Laser power for 785 nm

Laser Power adjustment

< -25°C TE-cooling (from +20°C ambient)

Deep Cooled Camera

Type of Scientific Sensor

96 wells in < 1 minute (@532nm) @ 500 msec exposure time per well

Reading Speed

Plate Format

Self-calibration

Door

Server Control

Footprint

PoliSpectra® RPR for HTS

Ultra
 Flexibility and High Performance for Advanced Applications

1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 High spectral and spatial resolution

2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 Fast confocal analysis

3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 Fully achromatic spectrometer spectral range - 200 nm to 2200
 nm (rephrase)

4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 LabSpec 6 supports multimodal imaging, analysis, and
 ParticleFinder™ for particle classification

LabRAM Odyssey

Confocal Raman & High-Resolution Spectrometer

✅Subpopulation | ✅Size | ✅Concentration | ✅ Fluorescence | ✅Sedimentation &nbsp;Exosomes? Virus? Nanoparticle? Use multiple lasers for complete, detailed analysis of all the particles in your sample.Exosomes, viruses, and nanoparticles all have wide size distributions which defeat traditional Nanoparticle Tracking Analysis (NTA) analyzers. The ViewSizer 3000 features simultaneous measurement with three lasers to collect the most accurate distribution and concentration information over a wide range of sizes within the same sample.&nbsp;&nbsp;Where the signal from a particle is too bright and saturates the detector from one laser, the software automatically uses data from a lower power laser to ensure the most accurate size and concentration information. On the other hand, when scattering from one laser is too weak for detection, the software uses data from a higher power laser to accurately track the particle.&nbsp;Cross contamination is a concern in all analyses. Simplified cleaning means thorough cleaning. The easy-to-remove sample cells can be dissassembled for rapid, thorough cleaning, which leads to better data.

ViewSizer 3000

Simultaneous Multi-Laser Nanoparticle Tracking Analysis

The FluoroMax®&nbsp;Plus represents HORIBA's&nbsp;industry-leading fluorometer performance in a convenient, affordable, easy-to-use benchtop model. The FluoroMax&nbsp;family, with its unique all reflective optics and photon counting was the first to bring the sensitivity of a modular fluorometer to a tabletop fluorescence instrument, in the 1990's.&nbsp;It’s a compact spectrofluorometer, yet offers the ultimate sensitivity in fluorescence investigations as well as features not found in most table-top fluorescence detection systems.&nbsp;The FluoroMax Plus is the latest generation of the original, high performance tabletop fluorometer, which offers extended performance with detection of emission spectra out to 1700 nm and (TCSPC) Time Correlated Single Photon Counting lifetime measurements as short as 25ps.

FluoroMax Plus(ls)

Sensitive, Flexible, Trusted Spectrofluorometer

FluoroMax Plus

Duetta™ is a 3-in-1 spectrofluorometer that combines the functions of fluorescence and absorbance spectrometers simultaneously. Thanks to its high-speed, built-in CCD detector, the Duetta can acquire a full spectrum from 250 nm to 1,100 nm in less than one second, making it the fastest fluorescence spectrometer on the market.&nbsp;Duetta uses A-TEEM™ technology to acquire absorbance, transmission, and fluorescence EEMs simultaneously – a true 3-in-1 instrument that corrects for the inner filter effect on the fly.&nbsp;Data acquisition is more accurate because measurements are taken from the same spot without moving the sample and repeating the exercise.&nbsp;To aid in the use of the Duetta and teach fluorescence spectroscopy principles in an undergraduate teaching laboratory setting, we have made a series of education labs. Designed to teach some of the most important concepts in fluorescence spectroscopy, these education labs can be used as is, or tailored to fit the needs of any undergraduate laboratory.

Duetta(ls)

The HORIBA Aqualog is a unique optical spectrometer that is the gold standard in environmental water research around the world for the study of color dissolved organic matter (CDOM).&nbsp;The Aqualog was invented to meet the needs of environmental water researchers around the world studying CDOM using fluorescence spectroscopy. At that time researchers were using scanning spectrofluorometers to slowly acquire a three dimensional matrix of the fluorescence excitation and fluorescence emission spectra, called an Excitation Emission Matrix (EEM). The EEM provides a fingerprint for studying dissolved organic matter, however it took up to an hour to collect a single EEM profile, tying the researcher to the lab bench for the entire day.&nbsp;&nbsp;The HORIBA Aqualog vastly improves the speed with which fluorescence EEMs are collected, dramatically increase the dynamic range across which EEM fingerprints are quantitative, and simultaneously acquires absorbance spectra for absorbance and color analysis of non-fluorescent molecules present in water. We call this technique that the Aqualog employs, an Absorbance-Transmission Excitation Emission Matrix, or <a href="https://www.horiba.com/int/scientific/products/fluorescence-spectrometers/a-teem/">A-TEEMTM</a>.

Aqualog

&nbsp;See the True Characterization of Your ParticlesThis latest evolution in the LA series advances scientific knowledge for tomorrow's world through intuitive software, unique accessories, and high performance.The LA-960V2 continues HORIBA's proud tradition of leading the industry with innovative design.&nbsp;

partica LA-960V2(ls) 

Laser Scattering Particle Distribution Analyzer

MacroRAM™ is an easy-to-use macro Raman spectrometer for fast and reliable Raman analysis. Perfect for bulk analysis of solids, liquid solutions, powders, and gels, MacroRAM provides the flexibility and sensitivity to handle virtually any type of sample. With a compact and robust design including Class 1* laser safety, MacroRAM is ideal for use in most environments, from undergraduate teaching labs to industrial QC and manufacturing.&nbsp;Powered by the industry-leading LabSpec 6 spectroscopy suite software, MacroRAM brings simplicity to macro Raman spectroscopy without compromising the ability to handle even the most challenging applications. It is ideal for confirming the identity and quality control of incoming raw materials, as well as for analyzing chemical composition, process monitoring, and assessing unknown substances. MacroRAM's durability and fixed internal setup ensure consistent and reproducible results over time, making it a reliable and robust choice for researchers, scientists, and industry professionals across such disciplines as pharmaceuticals, polymers &amp; microplastics, forensics, wet chemistry, gemology, and other industries.&nbsp;To facilitate the use of the MacroRAM in the undergraduate teaching laboratory setting, a series of educational labs are available. Designed to teach some of the most important concepts in Raman spectroscopy, such as identification, quantification, and vibrational chemistry, these educational labs can be used as is or tailored to fit the needs of any undergraduate laboratory. To learn more about these labs, please visit&nbsp;<a href="https://www.horiba.com/int/scientific/products/raman-imaging-and-spectrometers/macroram-educational-labs/">MacroRAM Educational Labs</a>.